GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs12780845 | 1 | rs2181043 | chr10:17217803 | CUBN | chr10:16865966-17171816:- | 0.31 | 4.9 | 4.0E-6 | Homocysteine levels |
| THYM | cis | rs7072122 | 1 | rs2184768 | chr10:45046562 | ZNF22 | chr10:45496273-45500776:+ | 0.47 | 4.63 | 1.16E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs2184769 | chr10:45050050 | ZNF22 | chr10:45496273-45500776:+ | 0.4 | 4.31 | 3.95E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs2184770 | chr10:45049680 | ZNF22 | chr10:45496273-45500776:+ | 0.46 | 4.66 | 1.04E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs8078723 | 1 | rs2227336 | chr17:38174855 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -9.32 | 4.71E-15 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs9369898 | 1 | rs2229384 | chr6:49425521 | CENPQ | chr6:49431096-49460820:+ | 0.3 | 4.78 | 6.27E-6 | Homocysteine levels |
| THYM | cis | rs2239557 | 1 | rs2239557 | chr14:74551970 | LIN52 | chr14:74551656-74667117:+ | 0.38 | 7.1 | 2.22E-10 | Common traits (Other) |
| THYM | cis | rs9876781 | 1 | rs2242150 | chr3:48505964 | TREX1 | chr3:48501186-48509043:+ | 0.29 | 4.28 | 4.47E-5 | Longevity |
| THYM | cis | rs2273 | 1 | rs2242471 | chr4:76878716 | NAAA | chr4:76831809-76862166:- | 0.46 | 4.92 | 3.56E-6 | Longevity |
| THYM | cis | rs2273 | 1 | rs2242473 | chr4:76878956 | NAAA | chr4:76831809-76862166:- | 0.46 | 4.92 | 3.56E-6 | Longevity |
| THYM | cis | rs2273 | 1 | rs2242474 | chr4:76878982 | NAAA | chr4:76831809-76862166:- | 0.46 | 4.92 | 3.56E-6 | Longevity |
| THYM | cis | rs2243480 | 1 | rs2243480 | chr7:65599196 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.73 | 7.78E-6 | Diabetic kidney disease |
| THYM | cis | rs2251844 | 1 | rs2245715 | chr15:43818052 | ADAL | chr15:43622872-43646094:+ | -0.63 | -5.3 | 7.39E-7 | Tumor biomarkers |
| THYM | cis | rs2463822 | 1 | rs2246920 | chr11:62104937 | ASRGL1 | chr11:62104774-62160885:+ | 0.56 | 5.84 | 7.18E-8 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs2806864 | 1 | rs2247145 | chr1:117470312 | SLC22A15 | chr1:116519119-116612672:+ | -0.64 | -4.7 | 8.76E-6 | Erectile dysfunction and prostate cancer treatment |